Diphenidine

(DPD, DND, 1,2-DEP)

TrippyWiki score: 3.6/10

What is Diphenidine?

Diphenidine is a dissociative substance of the diarylethylamine class. The drug causes similar effects to those of O-PCE, 3-MeO PCP, and other PCP/PCE related drugs. It also shares some similarities with ketamine and other dissociatives. It was invented as a replacement for more popular MXE and is extremely similar to MXM. The main difference between Diphenidine and MXE is that Diphenidine tends to be more sedative and less stimulating, while allowing you to stay more “functional” during the drip.

Long-term benefits & side effects

Many of the benefits will only occur if you take this substance the right way.
Some of the side effects are preventable if you follow the harm reduction practices below.

Diphenidine…

Can be an effective way to temporarily lower depression, stress, and anxiety (typically for 1-2 weeks after the drug leaves your system)
Works instantly, therefore it helps prevent suicide
Can cause temporary ego-dissolution at higher doses
May increase neuroplasticity
Makes users more creative and open-minded
Helps you introspect and look at your life from a different perspective
Allows you to forgive people who’ve hurt you
…

Can be lethal if taken at very high doses and mixed with other drugs (although death is an extremely rare side effect)
Might lead to drug-induced psychosis even if you’re not predisposed to it (and this side effect is more common than for some other dissociatives like ketamine)
Appears to be neurotoxic for those who take it regularly
Might impair your memory, especially if you take the substance every week or more often
Can cause schizophrenia-like symptoms and might speed up the onset of schizophrenia if you’re genetically predisposed to it
Might cause bladder pain and can lead to long-term urinary tract and bladder damage
Can cause HPPD and physical damage if you combine it with other substances (such as alcohol or stimulants)
Could cause you trauma due to bad set and setting
Can be psychologically addictive (but only if you use the psychedelic recreationally)
Can damage your kidneys over time
Is more addictive and habit-forming than ketamine and a few other dissociatives
Typically leads to depression when taken on a regular basis
Speeds up cognitive decline
Can lead to manic episodes, even if you are not predisposed to bipolar disorder
Can cause seizures when combined with other substances
May lead to heart problems for those who are predisposed to them
May get you imprisoned as the drug is not legal in most countries
Has led to rhabdomyolysis (rapid muscle breakdown) in some users, although this is rare
…

How to take Diphenidine

Administration

Since Diphenidine is taken in relatively small amounts, you need to use an extremely accurate, 0.001g scale.

You can either take the substance intramuscularly, intravenously, orally, vaporize it, or snort it.

Most users prefer snorting Diphenidine. The drug is then more stimulating and euphoric. It also kicks in faster than if you were to take Diphenidine orally.

Those who snort Diphenidine tend to become addicted to it more often and are more likely to redose compulsively.

You can take the substance sublingually or rectally as well. This route leads to an even faster onset.

The drug can also be swallowed. When taken orally, Diphenidine is more dissociative and less stimulating than with other routes.

Interestingly, the higher the dose you take, the less it matters which route of administration you chose as far as the effects of the drug.

Dosage

30 mg = Threshold
40-65 mg = Light dose
65-100 mg = Regular dose
100-130 mg = Strong dose
130+ mg = High dose

High doses are not recommended since they can lead to mania and psychosis. This is not nearly as likely to happen as with most PCP/PCE related dissociatives, but the possibility is real. Never take such a high dose if you value your mental health.

Never start with a strong dose. You may be more sensitive to the substance than others and it might cause you irreversible damage if you don’t take it responsibly.

Those who need less of the substance to reach desired effects include older and extremely lean people.

Since tolerance to Diphenidine is developed rather quickly, you want to wait for at least 1-2 weeks between dosing. Otherwise, you would need a higher dose to reach the desired outcome.

Safety checklist

Maximize the benefits

Keep in mind that integration is even more important than the trip itself. Taking the drug would be almost useless if you didn’t retain any lessons in your day-to-day life.

What will help you the most is contemplating about the experience – be it by journaling, thinking about the trip, or sharing your memories with a trusted friend.

Distracting thoughts can get in the way, which is why you want to spend the day after your trip without TV, social media, and other distractions.

If you can, spend time in silence and solitude. Meditate, go for a walk, contemplate the experience.

Duration

Onset = 15-30 minutes
Come up = 30-60 minutes
Peak = 30-90 minutes
Come down = 1-2 hours

You should notice the first effects within 20 minutes after you take the psychedelic
You will reach the maximum effect around the 1-hour mark
The whole trip usually lasts for 2-5 hours
At high doses, your trip may last for even longer
It’s common to feel altered for up to a day after you’ve taken the drug, especially when you take a high dose

What does Diphenidine feel like?

The effects of Diphenidine are almost identical to MXM and comparable to those of MXE. There also are similarities between other dissociatives, such as ketamine and 3-MeO PCP.

The main difference between Diphenidine and MXM is that the warmth and euphoria sometimes leaves your body faster on Diphenidine.

Diphenidine is less stimulating than most drugs from the PCP/PCE family but it is less stimulating than MXE.

Compared to MXE, Diphenidine gives you a different body high and allows you to stay more “functional”, which means you can still do daily tasks on lower doses.

Diphenidine is less likely to throw you into psychosis or mania than PCP and its relatives, although it can happen if you use the drug more than once a week.

Ketamine is more psychedelic than Diphenidine while Diphenidine is more predictable and more enjoyable for most people.

MXE is more ketamine-like than Diphenidine. Diphenidine gives you less anxiety but there is also less therapeutic potential because the drug doesn’t allow you to process your trauma as effectively.

At high doses, Diphenidine can cause hallucinations that are less predictable than with most psychedelics or dissociatives.

As a dissociative, Diphenidine can detach you from your body, senses, and environment. You may feel like you’re controlling your body from a distance (similarly to playing a 3rd person video game).

At high doses, you may also enter the K-hole. When that happens, you will not be conscious of your body but with Diphenidine, you may still be able to move around so never take a high dose in an unsafe environment!

Memory loss is a common effect. This can be pleasant because you’ll forget about your struggles, but it can also make you anxious since you may not remember where you are or that you’ve taken Diphenidine.

Other common short-term effects include:

Euphoria
Increased creativity and open-mindedness
Mindfulness, being present
Introspection
Higher capability for love and compassion
Pain relief
Memory suppression
Anesthetic effects
Numbness
Visual effects (typically weak and unpredictable)
Distortions of size, shape, and distance
Manis
Psychosis
Confusion
Inability to talk
Increased body pressure
Worse thermoregulation
Difficulty urinating
Anxiety, paranoia
Vulnerability

The higher dose you take, the more intense these effects will be. This especially applies to the dissociative effects.

Your past experiences with drugs also play a big role in the effects of Diphenidine.

With all this said, it is impossible to accurately describe the experience through human language.

Bad trips can happen but you can partially prevent them by following the tips below.

After-effects

Diphenidine rarely causes a withdrawal. If you take the drug on a regular basis, some withdrawal symptoms may occur but they will be mild.

It is, however, common to feel altered for up to 48 hours after you’ve taken Diphenidine, especially when you take a high dose.

You may experience insomnia and find it hard to fall asleep.

Cognitive impairment, numbness, and impaired vision can also stick for over a day after taking the drug. Do not drive if you don’t feel 100% sober!

Many users get a pleasant afterglow when the drug wears off. They feel better and their depression can disappear for a few days, sometimes even weeks.

Bad trips

Bad trips mostly happen because people take the substance irresponsibly. If you take this drug the right way, there is a much lower chance you’ll get a bad trip but it still can happen.

In case you take Diphenidine responsibly and you still get a bad trip, there is a positive side to that.

During a “bad” trip, negative emotions are coming up from your subconscious mind. They have always been there whether you are aware of it or not. They have been damaging your life and a difficult trip is an opportunity to process these traumas and unpleasant feelings and let go of them.

So instead of calling bad trips bad, call them challenging.

Why they happen

The most common reasons for getting a bad trip are:

Tripping in an unsafe environment (in public, at a party, even nature doesn’t feel safe if you take higher doses)
Facing difficult times in your day-to-day life (a break-up, death of a loved one, …)
Rejecting to let go and trying to hold on to your ego and control the state
Being afraid of the trip (either because of the stigma around psychedelics or because you are not sure how pure your substance is)
Mixing the psychedelic with alcohol, weed, or other drugs
Expecting a bad trip (it can easily become a self-fulfilling prophecy)
Taking a high dose

How to cope with a bad trip

Do not perceive this experience as something bad, remember that facing these difficult emotions can be extremely healing
Fully surrender to the experience, do not try to feel good
If you’re alone, call a trusted friend to come over and keep you safe

How to end a bad trip

In case you are not ready to face your inner demons yet, there are a few ways to end a bad trip.

One possible way is to put on music that is familiar to you. Another way is to switch up your location and move from one place to another. This can completely change your train of thought.

Interactions

Qualia Mind
This nootropic is comprised of 28 ingredients designed to support and maximize your brain function. These ingredients act synergistically and many of them will protect you from the neurotoxic effects of psychedelics. Qualia will also make your trips more pleasant and help you retain more benefits from them.
Herbs
Herbs can help calm you down. Herbal teas (chamomile, lemon balm, valerian root, …) are especially helpful.
Green tea
Tea makes you both more alert and calm at the same time. It also contains neuroprotective antioxidants, such as EGCG.
CBD
CBD has a calming effect.
Weed
Marijuana will greatly intensify the trip.
Nitrous oxide
Nitrous oxide will multiply the intensity of your trip.
Benzodiazepines (Valium, Xanax, …)
The combination may lead to a loss of consciousness and vomiting. Vomit aspiration is the most dangerous risk.
Alcohol, GHB, GBL, Opioids
Just like benzodiazepines, these drugs can cause vomit aspiration if you combine them with dissociatives. Dissociatives can also reduce opioid tolerance, increasing the risk of overdose.
SSRIs or MAOIs
Not only will these antidepressants greatly decrease the intensity of your trip, but they can also lead to long-lasting side effects. You may also go unconscious and die from vomit aspiration.
Stimulants
The combination can lead to heart problems or hyper mania.
Tramadol
Combining the two can cause seizures.

Legality

As of 2021, Diphenidine is illegal in most countries of the world.

In some European countries, you may be able to buy the drug for “chemical research” purposes. You cannot consume it legally but whether or not anyone cares is a different story.

In many countries, you can own a small amount of the substance for personal use without getting in legal trouble.

FAQ

Yes. Tolerance develops quickly and can last for months or even years.

However, it usually takes 3-7 days to cut the tolerance in half and by 2 weeks, most users will be as sensitive to Diphenidine as if they never took it before.

Diphenidine also has cross-tolerance with other dissociatives, like ketamine and DXM.

Diphenidine acts primarily as an NMDA receptor antagonist, meaning it binds to and blocks the activity of the NMDA receptor, the receptor responsible for the transmission of neural impulses in the central nervous system.

Always take the substance in a safe place and keep a trusted friend nearby to take care of you in case something goes wrong.

Unfortunately, the answer is yes. High doses of Diphenidine can lead to mania and drug-induced psychosis. With that said, this doesn’t happen nearly as common as with most PCP/PCE-related dissociatives.

The drug stays in your blood for around 24 hours, in your saliva for up to 2 days, in your urine for 14-30 days and in your hair, the substance can be detected for a few months.

Keep your powder or liquid in a cold dark place, preferably with no air.

If you don’t do this, the drug will lose potency over time.

It is recommended to stop eating 2-3 hours before taking the substance, especially if you take it orally.

Alcoholics
Those who don’t want to put their mental health at risk
Brain cancer patients
Those who have uncontrolled hypertension (high blood pressure)
People with a history of heart attacks
People with thyroid disease (hyperthyroidism and hypothyroidism)
Immature psychonauts who are not willing to follow the safety guidelines
People who suffer from psychosis
People who have a familial history of schizophrenia
Those who suffer from HPPD
People who are are predisposed to bipolar disorder or are going through a manic phase
Those who tried other dissociatives and noticed unpredictable side effects

Compared to most other dissociatives, Diphenidine is quite addictive because of its euphoric effects. This is especially the case for users who take the substance with the purpose of having fun.

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