5-MeO-DMT

(The God Molecule, Toad Venom)

TrippyWiki score: 9.1/10

What is 5-MeO DMT?

5-MeO-DMT (5-methoxy dimethyltryptamine) is a psychoactive substance of the tryptamine class. The drug is believed to be the most intense psychedelic substance in the world. In fact, users say it is 10-20 times stronger than regular DMT. 5-MeO DMT comes from the Colorado River Toad (Bufo Alvarius) but can also be extracted from certain plants, such as Yopo, or created synthetically.

Why choose 5-MeO-DMT over other psychedelics?

5-MeO–DMT…

Has the biggest potential for transforming your mind
Will help you understand the nature of reality and can accelerate your path to enlightenment
Causes little to no visual effects so you will not get distracted by them
Usually doesn’t cause nausea or physical discomfort
Is anti-addictive
Doesn’t make you develop tolerance
Is physically safe and it doesn’t seem to cause any long-term damage to your organs if you take the recommended doses (otherwise, it could be fatal)
Is the most effective substance for clearing your energetic blockages
Lasts for a short amount of time
Is the single most effective way to have non-dual experiences
Has been shown to reduce stress and anxiety more than most other substances

Long-term benefits & side effects

Many of the benefits will only occur if you follow the tips below.
Most (if not all) of the side effects are preventable and they will not happen if you follow the Safety checklist.

5-MeO-DMT…

Can lower your levels of stress and anxiety, including social anxiety (a single dose causes a 40-60% decrease 1 month after dosing)
Is extremely effective for treating depression (a single dose can decrease the symptoms by 20-40% and the effects last for a long amount of time)
Can help you reach enlightenment
Is being used to cure addictions
Might help you form positive habits, such as meditation and exercise
Increases neuroplasticity
Makes you more creative and open-minded
Helps you look at your life from a different perspective
Allows you to heal your childhood trauma and forgive people who’ve hurt you
Makes you more conscious and loving
Can help you transcend the fear of death
Gives you insights into the nature of reality
Makes you appreciate nature more
…

Can be fatal if you take extremely high doses
Has led to self-harm by people who took it in an unsafe environment
Might speed up the onset of schizophrenia if you’re genetically predisposed to it
Can cause HPPD and physical damage if you combine it with other substances (such as alcohol or stimulants)
Could cause you trauma due to bad set and setting
Might lead to drug-induced psychosis if you’re predisposed to it
Can cause seizures in rare cases
Is illegal in most places and you might get arrested for getting involved with the substance
…

How to take 5-MeO DMT

Always test your substance with a Marquis Reagent Testing Kit before you put it in your mouth.

Administration

There are 4 main ways to take 5-MeO DMT: smoking, snorting, plugging the substance or taking it intramuscularly.

Each of these will lead to a similar experience but the duration and the intensity of your trip will vary greatly.

Of those 4, smoking is the most popular method but also the least recommended.

Not only are we not sure about the long-term effects of 5-MeO on your lungs but the onset is also incredibly fast. This may feel overwhelming and it is the reason why people tend to get less paranoid when they use different routes of administration.

You may also find Ayahuasca that contains 5-MeO DMT but it is uncommon and may not be as safe as other routes of administration because Ayahuasca contains MAOIs and combining the two can be dangerous.

How to smoke 5-MeO DMT

The easiest way to smoke 5-MeO DMT is with a glass pipe. Make sure that it ends with a ball. The bigger the ball, the better.

If you have a torch lighter that creates a blue flame, use it instead of a regular lighter.

Before you smoke the substance, put a metal tray or a ceramic plate next to you. The pipe will be hot and you don’t want to burn your carpet or set your neighborhood on fire.

If you have a trip-sitter, let him hold the pipe as you are inhaling.

Hold the fire 2-3 inches (5-8 cm) below the pipe. Rotate the pipe and wait for the drug to turn into smoke.

The smoke should be very light and clear. If it’s thick, you’re probably overheating the substance.

Inhale the smoke slowly and gently, then hold it in your lungs until you start tripping.

You don’t need to consciously exhale. The longer you hold the smoke in your lungs, the more intense the experience will be.

How to snort 5-MeO DMT

Split the dose into halves and snort the substance to both of your nostrils.

Lay down to not let the drug fall out of your nose.

Do not snort a freebase version of 5-MeO. It isn’t dangerous but your nose will burn. It feels similar to snorting cayenne pepper.

How to plug 5-MeO DMT

Empty your bowels before you take the substance rectally.

Mix every 10 mg of the drug with 0.1 ml of filtered water. Let the drug completely dissolve into the water.

If you’re using a freebase form, add 2-3 drops of white vinegar into the mix to convert the substance into 5-MeO acetate.

Use a 1 ml syringe, put the liquid into it and plug the substance into your a#s.

You need to put the syringe deep enough but not too deep either. What will help you achieve this is putting a rubber band around the 0.6 ml. That way, you will know when to stop.

After you pour the liquid into your system, wait for 1-2 minutes, then pour the syringe out and go lay on your bed or the ground.

Plugging seems to be the most efficient way to take 5-MeO because it will allow you to trip for much longer than if you were to smoke or snort the drug.

Some people don’t notice any effects when they plug the substance but this isn’t common.

Dosage

Never take over 30 mg or 5-MeO DMT. Taking this much isn’t necessary and could be fatal!

Whatever form or dose you are going to take, make sure to use an accurate, 0.001g scale or a micro scoop to measure your substance. Micro scoops are cheaper and might be more accurate.

If you snort the substance, take 20% more than you otherwise would.

Synthetic

1-3 mg = Threshold dose
3-6 mg = Light dose
6-12 mg = Regular dose
12-20 mg = Strong dose
20+ mg = High dose

The freebase form is around 20% stronger than HCl. If you use the HCl version, multiply the numbers above by 1.2.

Natural (Toad Venom)

4-8 mg = Threshold dose
8-20 mg = Light dose
20-40 mg = Regular dose
40-80 mg = Strong dose
80+ mg = High dose

Many psychonauts recommend starting with a light dose but this isn’t necessarily the best way to go.

Counterintuitively, a low dose is more likely to cause you a bad experience than higher doses.

If you start with a low dose, your ego will try to hold on and it will have a hard time surrendering to the experience. This is one of the main causes of a bad trip.

Perhaps the most experienced user of 5-MeO, Martin Ball, recommends that if you decide to smoke 5-MeO, you should smoke enough. By that, he means 15-20 mg.

Do not, however, start with a high dose if you don’t have a trip sitter nearby.

Your weight also influences the dose you should take to some extent. If you weigh a lot, you might need to take more 5-MeO than other people.

Synthetic 5-MeO DMT vs. Toad Venom

Toad venom isn’t pure 5-MeO DMT. It contains a tiny amount of Bufotenine, which causes psychedelic effects on its own but the amount found in toad venom is so small that you will not notice it.

Some people do see a difference between a synthetic and a natural form. The reason is not chemical composition, the reason is their belief system which can have a huge impact on the way you experience the drug.

As far as the effects, there is no difference between natural and synthetic 5-MeO DMT.

However, toad venom is worse when it comes to dosing.

You will have to take a higher volume (more mg) of toad venom so you will not need to measure the dose as accurately but even if you measure it correctly, you can never know how much 5-MeO the venom contains.

Usually, 10-25% of the venom is pure 5-MeO DMT.

One problem with using the toad venom is that the toads (Bufo Alvarius) get overfarmed and they might go extinct in the near future.

If you care about the population of Bufo Alvarius, ditch the venom and go for a synthetic form.

Safety checklist

Maximize the benefits

Martin Ball recommends taking the substance 3 times in a row to process the emotions fully.

If you can keep your body symmetrical, do it. Once people lose symmetry on 5-MeO, they tend to go back into their ego.

Integration is an important part of the experience although if you stay aware during your trip, it may not be as important as with other psychedelics.

What will help you the most to integrate the experience is contemplating the experience – be it by journaling, thinking about the trip, or sharing your memories with a trusted friend.

Distracting thoughts can get in the way, which is why you want to spend the day after your trip without TV, social media, and other distractions.

If you can, spend time in silence and solitude. Meditate, go for a walk, contemplate the experience.

With that said, staying aware during the trip is more important than integration when it comes to 5-MeO DMT.

Duration

Smoked:
Onset = 5-60 seconds
Come up = 30-60 seconds
Peak = 5-15 minutes
Come down = 10-20 minutes

Snorted:
Onset = 1-5 minutes
Come up = 3-5 minutes
Peak = 10-40 minutes
Come down = 30-60 minutes

Plugged:
Onset = 5-10 minutes
Come up = 5-15 minutes
Peak = 45-120 minutes
Come down = 60-90 minutes

What 5-MeO DMT feels like

As the strongest psychedelic, 5-MeO DMT will likely give you the most intense experience of your life.

The drug is 10-20 times stronger than regular DMT. However, the two are not at all similar when it comes to their effects.

The toad venom isn’t nearly as visual as regular DMT. In fact, it only produces little to no visual effects.

When you smoke the substance, you may feel like you are dying.

This will feel extremely threatening to your ego but if you wish to have a pleasant experience, you will have to let go of your sense of self and surrender to the experience.

If you try to escape death, you will experience the worst emotions you can imagine before the substance leaves your system.

If you surrender and face your death, the following minutes will be the most pleasant and healing moment of your life.

Almost everybody who lets go reports dissolving becoming God (also described as Oneness, Love, Infinity, Infinite Consciousness, True Self, Everything, etc.).

The most common visual effect is seeing pure white light. Not only will you see pure white light but you will be the light. There is no other in this non-dual state.

Purging is another common effect of 5-MeO DMT. It allows you to clear your energetic blockages.

People usually purge by screaming, shaking, and sometimes vomiting. This is why it is important to have a trusted trip sitter nearby.

Some other short-term effects include:

Euphoria
Mindfulness, being extremely present
Extreme capability for love and compassion
Pain relief
Keeping your body in symmetry
Completely disconnecting from this reality
Feeling your emotions more intensely
Time distortion
Confusion
Increased body temperature
Increased heart rate
Anxiety, paranoia
Vulnerability

Of course, the higher dose you take, the more intense these effects will be and the higher the chance to reach a breakthrough.

With that said, the only way to truly know what 5-MeO DMT feels like is to take it.

The experience isn’t always positive. You can, however, minimize the chance of a bad trip.

Bad trips

Bad trips mostly happen because people are not ready to “die”. If you take 5-MeO DMT the right way, there is a low chance you’ll get a bad trip.

In case you still do, that’s good! A “bad” trip isn’t bad, it can actually be the most healing and insightful moment of your life!

During a “bad” trip, negative emotions are coming up from your subconscious mind. They have always been there whether you are aware of it or not. They have been damaging your life and a difficult trip is an opportunity to process these traumas and unpleasant feelings and let go of them.

So instead of calling bad trips bad, call them challenging.

If you understand that bad trips are awesome in the long-run, not only will you feel more comfortable diving into these challenging states, it will actually excite you!

Why they happen

The most common reasons for getting a bad trip are:

Rejecting to let go and trying to hold on to your ego and control the state
Tripping in an unsafe environment (in public, at a party, even nature doesn’t feel safe if you take higher doses)
Facing difficult times in your day-to-day life (a break-up, death of a loved one, …)
Being afraid of the trip (either because of the stigma around psychedelics or because you are not sure how pure your substance is)
Mixing the psychedelic with alcohol, weed, or other drugs
Expecting a bad trip (it can easily become a self-fulfilling prophecy)

How to cope with a bad trip

Do not perceive this experience as something bad, remember that facing these difficult emotions is extremely healing
Fully surrender to the experience, do not try to feel good

How to end a bad trip

In case the trip becomes extremely challenging and there is no one around you to keep you safe, consider ending your trip with a trip killer.

Using a trip killer usually is not the best idea because the bad emotions will stay unresolved and you will get little to no benefits from the experience. With that said, using a trip killer is smarter than harming yourself.

The 2 best options that you have for ending a bad trip are Phenibut and benzodiazepines.

Phenibut is generally safer. The downside is that it can take hours to kick in.

So to end a trip, use benzodiazepines but only do this if you completely have to.

Interactions

Qualia Mind
This nootropic is comprised of 28 ingredients designed to support and maximize your brain function. These ingredients act synergistically and many of them will protect you from the neurotoxic effects of psychedelics. Qualia will also make your trips more pleasant and help you retain more benefits from them.
Herbs
Herbs can help calm you down. Herbal teas (chamomile, lemon balm, valerian root, …) are especially helpful.
Green tea
Tea makes you both more alert and calm at the same time. It also contains neuroprotective antioxidants, such as EGCG.
CBD
CBD has a calming effect.
LSD or Magic mushrooms
5-MeO DMT is extremely strong on its own so be careful when mixing it with other psychedelics.
Ibogaine
The combination is being used to treat opioid addiction and it is the most powerful method we know of. As Dr. Joseph Barsuglia stated, “We’re finding that the combination of [5-MeO-DMT and ibogaine] is like… 1+1=5. It’s just exponential.” With that said, combining the two could be dangerous for those who have heart problems.
Weed
Marijuana will greatly intensify the trip.
Dissociatives
Combining dissociatives with psychedelics won’t necessarily cause you harm but it can be confusing and lead to bad trips.
Nitrous oxide
Nitrous oxide will multiply the intensity of your trip.
Benzodiazepines (Valium, Xanax, …)
Benzos will end your psychedelic experience within 40 minutes but using this method may cause you side effects in the long-run.
Alcohol
Alcohol minimizes all the potential benefits of a psychedelic experience. It also greatly increases your chance of having a bad trip.
MAOIs, SSRIs, and RIMAs
Combining these with 5-MeO DMT can lead to serotonin syndrome and might even be lethal.
Lithium
Combining psychedelics with lithium significantly increases the risk of seizures and psychosis.
Stimulants
The combination can easily lead to heart problems, even if you’re a healthy individual.
Tramadol
Combining the two can cause seizures.
St. John’s Wort
This combination may lead to serotonin syndrome.

History of 5-MeO DMT

Legality

As of 2021, 5-MeO DMT is illegal in the US and most other countries.

However, there are countries where 5-MeO DMT has been decriminalized. Therefore, taking the substance or owning a small amount of it will not get you in trouble.

In many countries, you can legally buy 5-MeO DMT from research chemical companies for research purposes. More on this below.

Where to get 5-MeO DMT

These are the ways you can get your hands on the psychedelic, ranked from the safest to the least safe:

Buy the drug from a research chemical company
In many countries, 5-MeO is not a controlled substance and you can legally buy it from an RC company, such as Chemical Collective. More on this below.
Become a research subject
In Denmark, 5-MeO DMT is permitted for research. You may be able to participate in the studies.
Attend a 5-MeO ceremony
Beware, that there are many fraud shamans in the toad venom community that can hurt you. If you decide to go this way, choose your guide wisely.
Buy 5-MeO DMT in-person
Whether you buy the drug from a random drug dealer or a trusted friend, you can’t know for sure what the powder contains. It can also be difficult to find a dealer who sells this substance.
Buy 5-MeO DMT from a hidden market
The 5-MeO DMT you will find on the dark web is more likely to be pure than if you buy it on the street. The problem of going this route is that most dark web markets are a scam (including current SilkRoad) and you might not receive anything.
Extract 5-MeO DMT from plants
6 plants that are proven to contain 5-MeO DMT. These include Yopo and Vilca. However, the amount found in them is tiny.
Make synthetic 5-MeO DMT
This method can be dangerous and will only be possible if you have a fully-equipped home laboratory and a deep knowledge of chemistry.
Milk Bufo Alvarius
Not only can this method be dangerous but you would also hurt the toad population. Do not go this route unless you have to.

Buying 5-MeO legally from the internet

In many countries, the substance is legal to buy as long as you buy it for “chemical research” purposes. You cannot consume it legally but whether or not anyone cares is a different story. These companies know that you’re not buying the drug to study it under a microscope.

Perhaps the best provider of research chemicals, including 5-MeO DMT, is Chemical Collective.

Their products are cheap, the company is extremely reliable and they will deliver the chemicals to you within 20 days. In case the package gets lost, you can ask them to send you a new one and they will.

5-MeO DMT may be a controlled substance where you live so always check the legality status for your country before you buy any substance.

If you don’t do that, the police won’t arrest you but you can’t expect to receive the package either.

FAQ

There is no such thing as tolerance to 5-MeO DMT. Technically, you could smoke it every 2 hours.

However, if you’re taking 5-MeO DMT with an intention to grow spiritually. you want to incorporate all lessons from the trip before you take the substance again.

If you smoke 5-MeO DMT on a regular basis, your trips will get more and more intense and you will naturally not want to trip so often. Becoming addicted to toad venom is nearly impossible.

5-MeO-DMT quickly passes the blood-brain barrier. It shares a similar chemical structure with the neurotransmitter serotonin, which means it can fit into some of the serotonin receptors in the brain where it acts as an agonist, meaning it stimulates the receptor – especially the 5-HT2A subtype of the serotonin receptor.

5-MeO-DMT can increase proliferation, survivability and accelerate maturation of newborn neurons.

With that said, the only way to truly know what this psychedelic does to your brain is to try it yourself.

Always smoke 5-MeO DMT in a safe place where you feel comfortable. Make sure there are no strangers around and that nobody will bother you during your trip. The only exception to this rule is if you attend a retreat.

It’s recommended to have a trip sitter next to you.

If you are a mentally stable individual who does not suffer from psychosis or have a predisposition to schizophrenia, there is virtually no way you would develop any mental illnesses because of taking this psychedelic.

No.

5-MeO DMT can be detected in your urine for around 24 hours after you’ve taken it.

With that said, you do not have to be afraid that anyone would test you for 5-MeO DMT.

5-MeO DMT has a distinct smell and taste that you cannot compare with anything else.

Most people do not like the taste of the smoke but it isn’t unbearable either.

Keep the powder in a cold dark place, preferably with no air.

If you don’t do this, the substance will quickly lose potency.

Yes. Martin Ball is an example of someone who became enlightened purely because of 5-MeO DMT.

The substance is the most powerful tool when it comes to having non-dual experiences that we know of. One session with this drug can help you experience what the most intense spiritual seekers won’t experience in their lifetimes.

With that said, you may still need to continue with your meditation/yoga practice to retain the experience of oneness.

Do not eat before you smoke the drug. It can cause you nausea and make you vomit.

If you need to eat some food, do so 4-5 hours before tripping and keep your meal light.

Yes, but it is not recommended.

The 5-MeO experience will be intense beyond what you can imagine. Having at least some experience with other psychedelics, such as LSD or magic mushrooms, will help you tremendously.

Beginner psychonauts
Immature people who are not willing to follow the safety guidelines
People who suffer from psychosis
People who have a familial history of schizophrenia
Those who suffer from HPPD
People who are going through a manic phase of bipolar disorder
If you’re going through extremely challenging times, you can take psychedelics but the trips might be unpleasant, beware of that

5-Methoxy N,N-Dimethyltryptamine.

On a dark market, a typical price for 5-MeO is around $180/gram. On the street, the substance would cost you twice as much. If you buy the substance from an RC company, it should cost you around $150 per gram but Chemical Collective is cheaper than most other RC companies at the time of writing this article.

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